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doi: 10.1016/0925-4439(93)90074-B, PMID: 9 KangYEdwardsLGThornalleyPJ

Our findings demonstrate that ATA offers significant neuroprotection against tramadol withdrawal, primarily by inhibiting the TWEAK/Fn14 pathway and subsequently promoting the CREB phosphorylation

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Women, on the other hand, generally have lower baseline creatine stores and tend to do well with a lighter daily dose, and some research points to added benefits around hormonal fluctuations